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KMID : 0380620210530060706
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Korean Journal of Food Science and Technology
2021 Volume.53 No. 6 p.706 ~ p.714
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Suppression of reactive oxygen species generation as a part of antioxidative effect of plant extracts
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Song Seon-Beom
Chung Gu-June
Jung Hee-Jin
Jang Jung-Yoon
Chung Hae-Young
Kim Nam-Deuk
Lee Ji-Hyeon
Min Kyung-Jin
Park Sun-Yeong
Kwak Chung-Shil
Hwang Eun-Seong
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Abstract
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Chemical scavenging of reactive oxygen species (ROS) is considered a major mechanism of antioxidant effects, but preventing ROS generation can be more efficient in attenuating oxidative damage. In this study, the extracts of plants, Solanum lycopersicum, Ailanthus altissima, Equisetum arvense, and Oenothera biennis, were tested to determine whether their antioxidative effects are driven by the prevention of superoxide generation from mitochondria, a major ROS generator. While all the extracts efficiently attenuated the elevation of ROS levels in human fibroblasts and inflammation-induced mice, those of S. lycopersicum, A. altissima, and O. laciniata only suppressed mitochondrial ROS generation and reduced levels of lipofuscin and lipid peroxidation. Furthermore, the extracts of A. altissima and O. laciniata extended the lifespan of fruit flies. Our results suggest that plant extracts with anti-oxidative effects differ in their ability to prevent ROS generation, which may be associated with the attenuation of oxidative damage in cells and animal tissues.
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KEYWORD
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Solanum lycopersicum, Ailanthus altissima, Equisetum arvense, Oenothera biennis, antioxidative effect, mitochondria ROS, lipofuscin
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